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Chemical Structure : INCB-3344
CAS No.: 1262238-11-8
Catalog No.: PC-45838Not For Human Use, Lab Use Only.
INCB-3344 (INCB3344) is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively, in MCP-1 binding assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $788 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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INCB-3344 (INCB3344) is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively, in MCP-1 binding assays.
INCB-3344 show no significant activity for murine CCR1 and murine CCR5 (IC50>1 uM), and a panel of >50 ion channels, transporters, chemokine receptors and other selected GPCRs.
INCB-3344 inhibits macrophage influx in a mouse model of delayed-type hypersensitivity, significantly reduces disease in models of multiple sclerosis, and inflammatory arthritis.
| M.Wt | 577.592 | |
| Formula | C29H34F3N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[2-[[(3R,4R)-1-[trans-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel- |
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1. Brodmerkel CM, et al. J Immunol. 2005 Oct 15;175(8):5370-8.
2. Xue CB, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7473-8.
3. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct;84(4):551-61.
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