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Chemical Structure : IRAK4-IN-28
Catalog No.: PC-60013Not For Human Use, Lab Use Only.
A novel potent, selective IRAK4 inhibitor with IC50 of 51 nM.
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A novel potent, selective IRAK4 inhibitor with IC50 of 51 nM; demonstrates inhibition of NF-κB activation and growth of the ABC subtype of DLBCL cell lines in vitro in combination with ibrutinib; shows tumor regression against mutant MYD88L265P DLBCL.
| M.Wt | 385.512 | |
| Formula | C21H31N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scott JS, et al. J Med Chem. 2017 Dec 11. doi: 10.1021/acs.jmedchem.7b01290.
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