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Chemical Structure : JBJ-04-125-02
Catalog No.: PC-72984Not For Human Use, Lab Use Only.
JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.
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JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM.
JBJ-04-125-02 displays excellent selectivity against a panel of 468 kinases using the KINOMEscan approach (S-Score (35)=0.02).
JBJ-04-125-02 increases apoptosis and efficacy in vitro and in vivo compared with either single agent alone when combined with osimertinib.
| M.Wt | 543.617 | |
| Formula | C29H26FN5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. To C, et al. Cancer Discov. 2019 Jul;9(7):926-943.K1088:Z1088K1088:Y1088K1088:X1088K1088:W1088K1088:V1088K1088:U1K1088:R1088
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