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Chemical Structure : JTV-519 hydrochloride
Catalog No.: PC-63282Not For Human Use, Lab Use Only.
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).
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JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).
Heart Arrhythmia
Phase 2 Discontinued
| M.Wt | 461.061 | |
| Formula | C25H33ClN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Darcy YL, et al. Mol Pharmacol. 2016 Aug;90(2):106-15.
2. Inagaki K, et al. Circulation. 2000 Feb 22;101(7):797-804.
3. Ito K, et al. Br J Pharmacol. 2000 Jun;130(4):767-76.
4. Nakaya H, et al. Br J Pharmacol. 2000 Dec;131(7):1363-72.
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