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Chemical Structure : K-777
Catalog No.: PC-61984Not For Human Use, Lab Use Only.
K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
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K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
K-777 induces CCR4 internalization, reduces cell surface CCR4.
| M.Wt | 641.5 | |
| Formula | C28H32F4IN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sato T, et al. Pharmacology. 2013;91(5-6):305-13.
2. Solari R, et al. Eur J Pharmacol. 2015 Sep 15;763(Pt B):169-77.
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