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Chemical Structure : KAI-407
Catalog No.: PC-61697Not For Human Use, Lab Use Only.
KAI-407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages).
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KAI-407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages); prevents blood stage parasitemia in mice (100mg/kg); orally bioavailable.
| M.Wt | 421.383 | |
| Formula | C22H14F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zeeman AM, et al. Antimicrob Agents Chemother. 2014;58(3):1586-95.
2. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.
3. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.
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