Chemical Structure : KDU-691
CAS No.: 1513879-19-0
Catalog No.: PC-61696Not For Human Use, Lab Use Only.
KDU-691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K).
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KDU-691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K)。
KDU-691 shows IC50 of 58 nM, 36 nM and 196 nM against P. falciparum (Pf, boold stages), P. yoelii (Py, schizont) and P. cynomolgi (Pc, hypnozoites) respectively。
KDU-691 shows fully protective effect against P. cynomolgi sporozoites in animal models.
M.Wt | 419.864 | |
Formula | C22H18ClN5O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(4-Chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]imidazo[1,2-a]pyrazine-6-carboxamide |
1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.
2. Zeeman AM, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.
3. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.
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