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Chemical Structure : KML-29
CAS No.: 1380424-42-9
Catalog No.: PC-45584Not For Human Use, Lab Use Only.
KML-29 is a potent, highly selective MAGL (monoacylglycerol lipase) inhibitor with IC50 of 15 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $256 | In stock | |
| 100 mg | $464 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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KML-29 is a potent, highly selective MAGL (monoacylglycerol lipase) inhibitor with IC50 of 15 nM.
KML-29 shows no cross-activity with FAAH or other serine hydrolases.
KML-29 potently inhibits 2-AG hydrolysis, but does not affect AEA hydrolysis.
KML-29 reduces inflammatory and neuropathic nociceptive behaviour without occurrence of cannabimimetic side effects.
| M.Wt | 549.4164 | |
| Formula | C24H21F6NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester |
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1. Ignatowska-Jankowska BM, et al. Br J Pharmacol. 2014 Mar;171(6):1392-407.
2. Pasquarelli N, et al. Neuropharmacology. 2015 Apr;91:148-56.
3. Chang JW, et al. Chem Biol. 2012 May 25;19(5):579-88.
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