Chemical Structure : KNK-437
CAS No.: 218924-25-5
Catalog No.: PC-42056Not For Human Use, Lab Use Only.
An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.
Packing | Price | Stock | Quantity |
---|---|---|---|
10 mg | $56 | In stock | |
25 mg | $120 | In stock | |
50 mg | $224 | In stock | |
100 mg | $416 | In stock |
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An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells; inhibits the acquisition of thermotolerance as developed by sodium arsenite, also inhibited at mRNA levels; shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors in vivo (up to 200 mg/kg).
Colon Cancer
Preclinical
M.Wt | 245.2307 | |
Formula | C13H11NO4 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 34 mg/mL |
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Chemical Name/SMILES |
1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo- |
1. Yokota S, et al. Cancer Res. 2000 Jun 1;60(11):2942-8.
2. Koishi M, et al. Clin Cancer Res. 2001 Jan;7(1):215-9.
3. Guo F, et al. Cancer Res. 2005 Nov 15;65(22):10536-44.
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