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Chemical Structure : KT-185
Catalog No.: PC-20131Not For Human Use, Lab Use Only.
KT-185 (KT185) is a potent, selective, irreversible and orally-active α/β-hydrolase domain 6 (ABHD6) inhibitor with IC50 of 0.21 nM.
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KT-185 (KT185) is a potent, selective, irreversible and orally-active α/β-hydrolase domain 6 (ABHD6) inhibitor with IC50 of 0.21 nM.
KT-185 inhibits ABHD6 in a 2-arachidonoyl glycerol (2-AG) hydrolysis assay (IC50=13.6 nM for the mouse recombinant enzyme expressed in HEK293T cells).
KT185 is selective for ABHD6 over diacylglycerol lipase β (DAGLβ) at 1 µM, but inhibits lysophospholipase 1 (LYPLA1) and LYPLA2 at 10 µM.
KT185 (5-10 mg/kg) inhibits ABHD6 activity in mouse liver and brain in vivo.
KT185 inhibits increases in the frequency of spontaneous inhibitory post-synaptic currents (sIPSCs) induced by nicotine in the rat ventral tegmental area (VTA) but does not reduce nicotine self-administration in rats.
| M.Wt | 519.65 | |
| Formula | C32H33N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ku-Lung Hsu, et al. J Med Chem. 2013 Nov 14;56(21):8270-9.
2. Matthew W Buczynski, et al. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1086-91.
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