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Chemical Structure : KU60648
Catalog No.: PC-72042Not For Human Use, Lab Use Only.
KU60648 is a potent, dual inhibitor of DNA-PK and PI3K, inhibits DNA-PK and PI3Kα/β/δ with IC50 of 8.6 nM and 4/0.5/0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 uM.
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KU60648 is a potent, dual inhibitor of DNA-PK and PI3K, inhibits DNA-PK and PI3Kα/β/δ with IC50 of 8.6 nM and 4/0.5/0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 uM.
KU-0060648 exhibits differential effects on growth inhibition, but is not profoundly cytotoxic in a panel of human cancer cell lines.
| M.Wt | 582.71 | |
| Formula | C33H34N4O4S | |
| Appearance | Solid | |
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1. Hinrichsen I, et al. Mol Carcinog. 2017 Jul;56(7):1816-1824.
2. Mamo T, et al. Biochem Biophys Res Commun. 2017 Apr 29;486(2):307-313.
3. Mol Cancer Ther. 2021 Sep;20(9):1614-1626.
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