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Chemical Structure : Ko-143
CAS No.: 461054-93-3
Catalog No.: PC-42054Not For Human Use, Lab Use Only.
Ko-143 is a nontoxic analog of fungal toxin fumitremorgin C and potent, orally bioavailable inhibitor of BCRP (ABCG2) with EC90 of 26 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 100 mg | $598 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Ko-143 is a nontoxic analog of fungal toxin fumitremorgin C and potent, orally bioavailable inhibitor of BCRP (ABCG2) with EC90 of 26 nM.
Ko-143 shows low activity against P-gp, MRP1 and other known drug transporter.
Ko-143 has an effect on the transport activity of both ABCB1 and ABCC1 at >1 uM.
Ko-143 reverses Bcrp-mediated drug resistance and markedly increases the oral availability of topotecan in mice.
| M.Wt | 469.5732 | |
| Formula | C26H35N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)- |
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1. Allen JD, et al. Mol Cancer Ther. 2002 Apr;1(6):417-25.
2. Weidner LD, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):384-93.
3. Ozvegy-Laczka C, et al. J Biol Chem. 2005 Feb 11;280(6):4219-27.
4. Elkind NB, et al. Cancer Res. 2005 Mar 1;65(5):1770-7.
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