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Chemical Structure : KuWal151
Catalog No.: PC-63470Not For Human Use, Lab Use Only.
KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively.
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KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively.
KuWal151 shows no activity against CLK3 (IC50>10 uM), exhibits selectivity versus DYRK1A and other DYRK kinases.
KuWal151 displays a potent antiproliferative activity in an array of cultured cancer cell lines (HCT-116 cell GI50=191 nM).
| M.Wt | 282.727 | |
| Formula | C16H11ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Walter A, et al. PLoS One. 2018 May 3;13(5):e0196761.
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