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Chemical Structure : LCZ-696
CAS No.: 936623-90-4
Catalog No.: PC-45432Not For Human Use, Lab Use Only.
Sacubitril/Valsartan (LCZ696) is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Sacubitril/Valsartan (LCZ696) is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).
Sacubitril/Valsartan (LCZ696) causes dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats.
Sacubitril/Valsartan (LCZ696) provides sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats; orally active.
| M.Wt | 957.99 | |
| Formula | C48H60N6Na3O10.5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5) |
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1. Gu J, et al. J Clin Pharmacol. 2010 Apr;50(4):401-14.
2. von Lueder TG, et al. Circ Heart Fail. 2015 Jan;8(1):71-8.
3. McMurray J, et al. Eur Heart J. 2015 Feb 14;36(7):434-9.
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