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Chemical Structure : LLL-12
Catalog No.: PC-60938Not For Human Use, Lab Use Only.
LLL-12 is a nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer.
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LLL-12 is a nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer.
LLL-12 inhibit STAT3 phosphorylation (tyrosine 705) and induces apoptosis in various breast, pancreatic, and glioblastoma cancer cell lines with IC50 of 0.16-3.09 uM.
LLL-12 also inhibits STAT3 phosphorylation induced by IL-6 and IFN-α in MM cells, but not STAT1, STAT2, STAT4 and STAT6 phosphorylation.
LLL-12 inhibits STAT3 DNA binding activity and STAT3-dependent transcriptional activity, but not STAT1.
LLL-12 exhibits potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model.
| M.Wt | 303.29 | |
| Formula | C14H9NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lin L, et al. Int J Cancer. 2012 Mar 15;130(6):1459-69.
2. Lin L, et al. Neoplasia. 2010 Jan;12(1):39-50.
3. Liu Y, et al. J Biol Chem. 2010 Aug 27;285(35):27429-39.
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