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Chemical Structure : LOXO-292
CAS No.: 2152628-33-4
Catalog No.: PC-60209Not For Human Use, Lab Use Only.
LOXO-292 (Selpercatinib, LOXO 292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $388 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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LOXO-292 (Selpercatinib, LOXO 292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively.
LOXO-292 displays >100-fold selectivity versus important off-targets.
LOXO-292 shows anti-tumor activty in the brain and periphery in RET-dependent tumor models in vivo.
| M.Wt | 525.613 | |
| Formula | C29H31N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile |
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1. Subbiah V, et al. Ann Oncol. 2018 Aug 1;29(8):1869-1876.
2. Cancer Discov. 2018 Aug;8(8):904-905.
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