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Chemical Structure : LY-2510924
CAS No.: 1088715-84-7
Catalog No.: PC-61317Not For Human Use, Lab Use Only.
LY-2510924 (LY2510924) is a potent and selective, cyclic peptide CXCR4 antagonist with IC50 of 0.079 nM, without apparent agonist activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $448 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LY-2510924 (LY2510924) is a potent and selective, cyclic peptide CXCR4 antagonist with IC50 of 0.079 nM, without apparent agonist activity.
LY-2510924 inhibits SDF-1-induced cell migration with IC50 of 0.26 nM and inhibits SDF-1/CXCR4-mediated intracellular signaling.
LY-2510924 exhibits inhibition of SDF-1-stimulated phospho-ERK and phospho-Akt in tumor cells.
LY-2510924 shows inhibition of tumor growth in human xenograft models with acceptable in vivo stability and a pharmacokinetic profile.
| M.Wt | 1189.45 | |
| Formula | C62H88N14O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 |
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1. Peng SB, et al. Mol Cancer Ther. 2015 Feb;14(2):480-90.
2. Cho BS, et al. Blood. 2015 Jul 9;126(2):222-32.
3. Galsky MD, et al. Cancer Res. 2014 Aug 15;20(16):4414.
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