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Chemical Structure : LY-2584702 free base
CAS No.: 1082949-67-4
Catalog No.: PC-43058Not For Human Use, Lab Use Only.
LY2584702 is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $488 | In stock | |
| 500 mg | Get quote |
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LY2584702 is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM; blocks phosphorylation of p70S6K in primary rat hepatocytes without affecting the phosphorylation of other signaling kinases, including GSK-3β and ERK1/2; inhibits phosphorylation of p70S6K in HCT116 colon cancer cells with IC50 of 0.1-0.24 uM, demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.
Solid Tumors
Phase 1 Discontinued
| M.Wt | 445.4161 | |
| Formula | C21H19F4N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 4.5 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]- |
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1. Estridge TB, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118.
2. Tolcher A, et al. Eur J Cancer. 2014 Mar;50(5):867-75.
3. Hollebecque A, et al. Eur J Cancer. 2014 Mar;50(5):876-84.
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