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Chemical Structure : LY-487379
CAS No.: 353231-17-1
Catalog No.: PC-61611Not For Human Use, Lab Use Only.
LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3.
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|---|---|---|---|
| 25 mg | $228 | In stock | |
| 100 mg | $598 | In stock | |
| 200 mg | $898 | In stock | |
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LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3.
LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2, markedly potentiates glutamate-stimulated [35S]GTPgammaS binding at hmGluR2.
LY-487379 potentiates synaptically evoked mGluR2 responses in rat hippocampal slices, modulates excitatory synaptic transmission in the rat globus pallidus.
| M.Wt | 452.446 | |
| Formula | C21H19F3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide |
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1. Johnson MP, et al. J Med Chem. 2003 Jul 17;46(15):3189-92.
2. Schaffhauser H, et al. Mol Pharmacol. 2003 Oct;64(4):798-810.
3. Poisik O, et al. Neuropharmacology. 2005;49 Suppl 1:57-69.
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