Chemical Structure : LZK PROTAC 17
CAS No.:
2763268-85-3
LZK PROTAC 17
Catalog No.: PC-24506Not For Human Use, Lab Use Only.
LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM.
LZK PROTAC 17 (250 nM) reduces colony formation of CAL33 and DETROIT562.
LZK PROTAC 17 induces dose- and time-dependent degradation of LZK in HNSCC cells harboring MAP3K13 amplification.
Physicochemical Properties
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M.Wt
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909.11
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Formula
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C48H58F2N10O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-1-((S)-2-((1r,3S)-3-(4-(2-((4-cyanopyridin-2-yl)amino)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)piperidin-1-yl)cyclobutane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
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References
1. Katerji M, et al. J Biol Chem. 2025 Mar 27:108452.
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