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Chemical Structure : Lenvatinib
CAS No.: 417716-92-8
Catalog No.: PC-42762Not For Human Use, Lab Use Only.
Lenvatinib (E7080) is a multitargeted kinase inhibitor with IC50s of 4/5.2/22/46 nM for VEGFR2/VEGFR3/VEGFR1/FGFR1 in cell free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $288 | In stock | |
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Lenvatinib (E7080) is a multitargeted kinase inhibitor with IC50s of 4/5.2/22/46 nM for VEGFR2/VEGFR3/VEGFR1/FGFR1 in cell free assays.
Lenvatinib (E7080) also inhibits PDGFR, Kit with IC50< 100 nM.
Lenvatinib (E7080) suppresses the phosphorylation of VEGF receptor-2 and FGF receptor 1 and inhibits proliferation of endothelial cellin vitro; orally active.
| M.Wt | 426.853 | |
| Formula | C21H19ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy- |
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1. Matsui J, et al. Int J Cancer. 2008 Feb 1;122(3):664-71.
2. Matsui J, et al. Clin Cancer Res. 2008 Sep 1;14(17):5459-65.
3. Ikuta K, et al. Clin Cancer Res. 2009 Dec 1;15(23):7229-37.
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