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Chemical Structure : Lificiguat
CAS No.: 170632-47-0
Catalog No.: PC-44126Not For Human Use, Lab Use Only.
Lificiguat (YC-1) is an NO-independent, superoxide-sensitive stimulator of sGC (soluble guanylyl cyclase) with EC50 of 18.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 100 mg | $388 | In stock | |
| 250 mg | $598 | In stock | |
| 1 g | Get quote |
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Lificiguat (YC-1) is an NO-independent, superoxide-sensitive stimulator of sGC (soluble guanylyl cyclase) with EC50 of 18.6 uM.
YC-1 elicits only minor effects on relaxation and cyclic GMP, increases the vasodilator potency of SNP and nitroglycerin (NTG) by 10 fold.
YC-1 markedly enhances SNP- and NTG-induced cyclic GMP formation at 3 uM.
| M.Wt | 304.3425 | |
| Formula | C19H16N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 51 mg/mL |
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| Chemical Name/SMILES |
2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]- |
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1. Mülsch A, et al. Br J Pharmacol. 1997 Feb;120(4):681-9.
2. Purohit R, et al. Biochemistry. 2014 Jan 14;53(1):101-14.
3. Friebe A, et al. Mol Pharmacol. 1998 Jan;53(1):123-7.
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