Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Linifanib
CAS No.: 796967-16-3
Catalog No.: PC-45859Not For Human Use, Lab Use Only.
Linifanib (ABT-869) is a potent multi-RTKs inhibitor of members of VEGFR and PDGFR families with IC50 of 4/3/3/14/4/66/190/170 nM for KDR/FLT1/CSF1R/KIT/FLT3/PDGFRβ/FLT4/Tie2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | $798 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Linifanib (ABT-869) is a potent multi-RTKs inhibitor of members of VEGFR and PDGFR families with IC50 of 4/3/3/14/4/66/190/170 nM for KDR/FLT1/CSF1R/KIT/FLT3/PDGFRβ/FLT4/Tie2, respectively.
Linifanib (ABT-869) shows much less active (IC50>10 uM) against other nonrelated tyrosine kinases, such as steroid receptor coactivator and EGFR.
Linifanib (ABT-869) inhibits RTK phosphorylation (IC50=2, 4, and 7 nM for PDGFRβ, KDR, and CSF-1R, respectively) and VEGF-stimulated proliferation (IC50=0.2 nM for human endothelial cells).
Linifanib (ABT-869) exhibits efficacy in human fibrosarcoma and breast, colon, and small cell lung carcinoma xenograft models (ED50=1.5-5 mg/kg, twice daily).
Linifanib (ABT-869) also is a small molecule inhibitor of necroptosis by targeting RIPK1 kinase
| M.Wt | 375.3989 | |
| Formula | C21H18FN5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)- |
|
1. Dai Y, et al. J Med Chem. 2007 Apr 5;50(7):1584-97.
2. Shankar DB, et al. Blood. 2007 Apr 15;109(8):3400-8.
3. Albert DH, et al. Mol Cancer Ther. 2006 Apr;5(4):995-1006.
4. Pierotti CL, et al. Biochem J. 2023 Apr 28:BCJ20230035.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
