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Chemical Structure : Lotamilast
CAS No.: 947620-48-6
Catalog No.: PC-61387Not For Human Use, Lab Use Only.
Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
Lotamilast (RVT 501, E6005) produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application.
Lotamilast (RVT 501, E6005) ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.
| M.Wt | 472.501 | |
| Formula | C26H24N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate |
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1. Ishii N, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):105-12.
2. Andoh T, et al. Exp Dermatol. 2014 May;23(5):359-61.
3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5;768:41-8.
4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec;26(12):1403-1408.
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