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Chemical Structure : M-2698
Catalog No.: PC-60433Not For Human Use, Lab Use Only.
A potent, selective, ATP-competitive, orally bioavailable and brain penetrant dual inhibitor of p70S6K and Akt1/3 with IC50 of 1 nM and 17 nM, respectively.
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A potent, selective, ATP-competitive, orally bioavailable and brain penetrant dual inhibitor of p70S6K and Akt1/3 with IC50 of 1 nM and 17 nM, respectively; displays relative selectivity against a panel of 264 kinases (only 6 kinases within 10-fold IC50 of p70S6K); inhibits the phosphorylation of p70S6K1 and Akt substrates, S6 (IC50=11 nM) and GSK3β (IC50=17 nM) in MDA-MB-468 cells, show proliferation inhibition of 9 breast cancer cell lines (IC50<2 uM); inhibits growth of human breast cancer xenografted tumors in mice.
| M.Wt | 449.862 | |
| Formula | C21H19ClF3N5O | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Machl A, et al. Am J Cancer Res. 2016 Mar 15;6(4):806-18.
2. Previs RA, et al. J Natl Cancer Inst. 2017 Jul 1;109(7).
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