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Chemical Structure : MF63
Catalog No.: PC-43462Not For Human Use, Lab Use Only.
MF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme, >1000-fold selectivity over other prostanoid synthases.
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MF63 is a potent, selective, and orally active mPGES-1 inhibitor with IC50 of 1.3 nM for human mPGES-1 enzyme, >1000-fold selectivity over other prostanoid synthases.
MF63 strongly inhibits guinea pig mPGES-1 (IC50= 0.9 nM) but not the mouse or rat enzyme.
MF63 selectively suppresses the synthesis of PGE(2), but not other prostaglandins inhibitable by NSAIDs, yet retains NSAID-like efficacy at inhibiting LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain, relieves pyresis and pain in preclinical models of inflammation.
| M.Wt | 378.81 | |
| Formula | C23H11ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 43 mg/mL |
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1. Xu D, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63.
2. Côté B, et al. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20.
3. Giroux A, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41.
4. Finetti F, et al. Endocr Relat Cancer. 2015 Aug;22(4):665-78.
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