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Chemical Structure : MI-538
CAS No.: 1857417-10-7
Catalog No.: PC-45727Not For Human Use, Lab Use Only.
MI-538 is potent and selective menin-MLL interaction inhibitor (IC50=21 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MI-538 is potent and selective menin-MLL interaction inhibitor (IC50=21 nM).
MI-538 shows the most potent binding affinity to menin (Kd = 6.5 nM) obtained for small molecule menin–MLL inhibitor reported to date.
MI-538 exhibits significantly increased activity, selectivity, polarity and pharmacokinetic profile over MI-136 and demonstrates a pronounced effect in a mouse model of MLL leukemia.
| M.Wt | 566.6006 | |
| Formula | C27H25F3N8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO; Need ultrasonic and warming |
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| Chemical Name/SMILES |
1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]- |
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1. Borkin D, et al. J Med Chem. 2016 Feb 11;59(3):892-913.
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