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Chemical Structure : MI 219
Catalog No.: PC-62086Not For Human Use, Lab Use Only.
MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX.
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MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX.
MI 219 disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells.
MI 219 inhibits tumor growth in mouse xenograft models.
| M.Wt | 552.468 | |
| Formula | C27H32Cl2FN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shangary S, et al. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8.
2. Peterson LF, et al. Leukemia. 2011 May;25(5):761-9.
3. Feng FY, et al. Neoplasia. 2016 Apr;18(4):213-22.
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