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Chemical Structure : MIV-247
Catalog No.: PC-60705Not For Human Use, Lab Use Only.
MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S).
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MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S).
MIV-247 displays high selectivity (>200-fold) overs other related cathepsins, inhibits mouse and cynomolgus monkey cathepsin S with Ki of 4.5 and 7.2 nM, respectively.
MIV-247 attenuates mechanical allodynia alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects in mouse model of neuropathic pain.
| M.Wt | 391.391 | |
| Formula | C17H24F3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hewitt E, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96.
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