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Chemical Structure : MK-4827
CAS No.: 1038915-60-4
Catalog No.: PC-42681Not For Human Use, Lab Use Only.
MK-4827 (Niraparib, MK4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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MK-4827 (Niraparib, MK4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
MK-4827 (Niraparib) inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10−100 nM range.
MK-4827 (Niraparib) is well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.
| M.Wt | 320.3883 | |
| Formula | C19H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]- |
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1. Jones P, et al. J Med Chem. 2009 Nov 26;52(22):7170-85.
2. Bridges KA, et al. Oncotarget. 2014 Jul 15;5(13):5076-86.
3. Mirza MR, et al. N Engl J Med. 2016 Dec 1;375(22):2154-2164.
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