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Chemical Structure : ML-162
CAS No.: 1035072-16-2
Catalog No.: PC-70154Not For Human Use, Lab Use Only.
ML-162 (ML162) is a small-molecule probe that selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 100 mg | Get quote |
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ML-162 (ML162) is a small-molecule probe that selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
ML-162 displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines.
ML-162 is a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
| M.Wt | 477.4 | |
| Formula | C23H22CI2N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide |
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1. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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