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Chemical Structure : ML-241
CAS No.: 1346528-06-0
Catalog No.: PC-45718Not For Human Use, Lab Use Only.
ML241 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).
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ML241 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM); blocks degradation of p97-dependent proteasome substrate with an IC50 of 3.5 uM; induces caspases 3 and 7 and potently blocks proliferation in HCT15 and SW403 cells.
| M.Wt | 372.46 | |
| Formula | C23H24N4O | |
| CAS No. | 1346528-06-0 | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name |
N-benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine |
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1. Chou TF, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312.
3. Fang CJ, et al. ChemMedChem. 2015 Jan;10(1):52-6.
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