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Chemical Structure : ML197
Catalog No.: PC-63477Not For Human Use, Lab Use Only.
ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
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ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
ML197 inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510 nM.
ML197 extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells;
| M.Wt | 376.434 | |
| Formula | C20H16N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8.
2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.
3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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