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Chemical Structure : MLKL inhibitor P28
Catalog No.: PC-21159Not For Human Use, Lab Use Only.
MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL.
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MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL.
MLKL inhibitor P28 is more potent than Necrosulfonamide (NSA, Cat#PC-42202) in preventing cell death after exposure to necroptotic stimuli at a concentration of 0.1 μM.
MLKL inhibitor P28 (3 uM) inhibited the expression of α-SMA, collagen-1, CXCL1/CXCL2, MLKL, and ICAM1 in HSC-LX2 cells.
MLKL inhibitor P28 suppressed TSZ-induced cytokine and chemokine production in monocytes.
MLKL inhibitor P28 reduced the expression of ICAM1 and CXCL1/2, which operate via a pathway different from the conventional necroptosis pathway.
Unlike the necrosulfonamide treatment, the P28 treatment did not induce cytotoxicity.
| M.Wt | 394.39 | |
| Formula | C20H18N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ju Hee Oh, et al. ACS Pharmacology & Translational Science, 2023.
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