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Chemical Structure : MLN1117
CAS No.: 1268454-23-4
Catalog No.: PC-42947Not For Human Use, Lab Use Only.
MLN1117 (INK1117,TAK-117, Serabelisib) is a potent, selective PI3K p110α inhibitor with IC50 of 15 nM, displays >300-fold selectivity over p110β/γ/δ and mTOR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $318 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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MLN1117 (INK1117,TAK-117, Serabelisib) is a potent, selective PI3K p110α inhibitor with IC50 of 15 nM, displays >300-fold selectivity over p110β/γ/δ and mTOR.
MLN1117 (INK1117,TAK-117, Serabelisib) inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC50 of 2 uM, significantly suppresses B cell proliferation driven by anti-IgM alone but not by anti-IgM plus IL-4.
MLN1117 (INK1117,TAK-117, Serabelisib) abrogates immune checkpoint mediated proliferation in peripheral T-cell lymphoma combined with alisertib.
| M.Wt | 363.37 | |
| Formula | C19H17N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.4 mg/mL (Need ultrasonic or warming) |
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| Chemical Name/SMILES |
Methanone, [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl- |
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1. So L, et al. J Biol Chem. 2013 Feb 22;288(8):5718-31.
2. Juric D, et al. Clin Cancer Res. 2017 Sep 1;23(17):5015-5023.
3. Islam S, et al. Oncotarget. 2017 Nov 1;8(59):100326-100338.
4. Yea SS, et al. PLoS One. 2014 Jun 10;9(6):e99486.
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