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Chemical Structure : ML RR-S2 CDA ammonium salt
Catalog No.: PC-43284Not For Human Use, Lab Use Only.
ML RR-S2 CDA ammonium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.
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ML RR-S2 CDA ammonium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles; shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C; also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP; demonstrates profound anti-tumor efficacy in established B16 melanoma.
| M.Wt | 724.604124 | |
| Formula | C20H30N12O10P2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15 mg/mL; H2O: 12.5 mg/mL |
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1. Corrales L, et al. Cell Rep. 2015 May 19;11(7):1018-30.
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