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Chemical Structure : MLS 0038949
Catalog No.: PC-62545Not For Human Use, Lab Use Only.
MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).
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MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).
MLS 0038949 suppresses vascular smooth muscle cell calcification combined with PHOSPHO1 inhibitor MLS-0263839.
MLS 0038949 eliminates AMP hydrolysis in DRG and spinal lamina II of dKO mice.
| M.Wt | 344.385 | |
| Formula | C17H16N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Street SE, et al. J Neurosci. 2013 Jul 3;33(27):11314-22.
2. Kiffer-Moreira T, et al. J Bone Miner Res. 2013 Jan;28(1):81-91.
3. Dahl R, et al. J Med Chem. 2009 Nov 12;52(21):6919-25.
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