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MRS-2500 tetraammonium

Chemical Structure : MRS-2500 tetraammonium

CAS No.: 630103-23-0

MRS-2500 tetraammonium (MRS2500 tetraammonium)

Catalog No.: PC-61411Not For Human Use, Lab Use Only.

A highly potent and selective antagonist of the platelet P2Y1 receptor with Ki of 0.78 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly potent and selective antagonist of the platelet P2Y1 receptor with Ki of 0.78 nM; inhibits ADP-induced aggregation of human platelets with IC50 of 0.95 nM; shows strong antithrombotic activity in mice.

Physicochemical Properties

M.Wt 629.29
Formula C13H18N5O8P2I.4NH3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,2S,4S,5S)-4-(2-iodo-6-(methylamino)-9H-purin-9-yl)-1-((phosphonooxy)methyl)bicyclo[3.1.0]hexan-2-yl dihydrogen phosphate

References

1. Kim HS, et al. J Med Chem. 2003 Nov 6;46(23):4974-87.

2. Hechler B, et al. J Pharmacol Exp Ther. 2006 Feb;316(2):556-63.

3. Gao ZG, et al. Mol Pharmacol. 2017 Sep 1. pii: mol.117.109660.

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