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Chemical Structure : MRS1845
CAS No.: 544478-19-5
Catalog No.: PC-22078Not For Human Use, Lab Use Only.
MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells.
MRS1845 attenuates neutrophil function and postshock acute lung injury.
| M.Wt | 398.42 | |
| Formula | C21H22N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1-(prop-2-yn-1-yl)-1,4-dihydropyridine-3,5-dicarboxylate |
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1. Harper JL, et al. Biochem Pharmacol. 2003 Feb 1;65(3):329-38.
2. Cindy Lee, et al. J Trauma. 2005 Jul;59(1):56-63; discussion 63.
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