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Chemical Structure : MRTX1719
CAS No.: 2630904-45-7
Catalog No.: PC-72393Not For Human Use, Lab Use Only.
MRTX1719 (MRTX-1719) is a potent, selective binder to the PRMT5-MTA complex, selectively inhibits PRMT5 activity in MTAP-deleted cells (HCT116 MTAP-deleted IC50=12 nM) compared to MTAP-wild-type cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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MRTX1719 (MRTX-1719) is a potent, selective binder to the PRMT5-MTA complex, selectively inhibits PRMT5 activity in MTAP-deleted cells (HCT116 MTAP-deleted IC50=12 nM) compared to MTAP-wild-type cells.
MRTX1719 demonstrated dose-dependent inhibition of PRMT5-dependent symmetric dimethylarginine protein modification in MTAP-deleted tumors that correlated with antitumor activity in tumor xenograft-bearing mice.
MRTX1719 is a novel synthetically lethal drug target for the treatment of MTAP-deleted cancers.
| M.Wt | 464.885 | |
| Formula | C23H18ClFN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile |
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1. Christopher R Smith, et al. J Med Chem. 2022 Feb 10;65(3):1749-1766.
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