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Chemical Structure : MSN-125
CAS No.: 1592908-16-1
Catalog No.: PC-60940Not For Human Use, Lab Use Only.
MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $598 | In stock | |
| 10 mg | $898 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM。
MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.
| M.Wt | 688.619 | |
| Formula | C36H38BrN3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-{1(S)-[[2(R)-Aminomethyl-6-(2-methoxy-ethoxymethoxy)-2,3-dihydro-benzofuran-3(S)-yl]-(4-bromo-benzyl)-carbamoyl]-2-phenyl-ethyl}-benzamide |
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1. Niu X, et al. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.
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