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MsbA inhibitor 1

Chemical Structure : MsbA inhibitor 1

CAS No.: 52535-76-9

MsbA inhibitor 1

Catalog No.: PC-63580Not For Human Use, Lab Use Only.

MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane; causes mislocalization of LPS to the cell interior, inhibits Δ5 strain with MIC of 0.2 ug/ml.

Physicochemical Properties

M.Wt 335.802
Formula C16H14ClNO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

References

1. Zhang G, et al. Proc Natl Acad Sci U S A. 2018 May 7. pii: 201804670.

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