Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NS-1209
Catalog No.: PC-61501Not For Human Use, Lab Use Only.
NS-1209 is a selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NS-1209 is a selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM.
NS-1209 display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes.
NS-1209 inhibits AMPA-induced currents in cortical neurons with IC50 of 0.15 uM.
NS-1209 blocks AMPA-evoked spike activity in rat hippocampus (ED50=6.1mg/kg).
| M.Wt | 516.57 | |
| Formula | C24H28N4O7S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Nielsen EO, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1492-501.
2. Erichsen HK, et al. Pain. 2002 Jul;98(1-2):151-61.
3. Langer M, et al. Neuropharmacology. 2011 Oct-Nov;61(5-6):1033-47.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
