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Chemical Structure : NS-1619
CAS No.: 153587-01-0
Catalog No.: PC-43063Not For Human Use, Lab Use Only.
NS-1619 (NS1619) is a selective large-conductance Ca(2+)-dependent K+ channel (BKCa channel) activator with EC50 of 3.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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NS-1619 (NS1619) is a selective large-conductance Ca(2+)-dependent K+ channel (BKCa channel) activator with EC50 of 3.6 uM.
NS-1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones at <30 uM, does not activate ATP-K+ channels.
NS-1619 concentration-dependently inhibits spontaneous activity in rat portal vein at 3-100 uM, activates the large conductance, Ca2+-sensitive channel, BKca and over the same concentration range it inhibits both KV and L-type Ca-channels.
| M.Wt | 362.2267 | |
| Formula | C15H8F6N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)- |
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1. Sellers AJ, et al. Br J Pharmacol. 1994 Nov;113(3):659-61.
2. Olesen SP, et al. Eur J Pharmacol. 1994 Jan 4;251(1):53-9.
3. Edwards G, et al. Br J Pharmacol. 1994 Dec;113(4):1538-47.
4. Lee K, et al. Eur J Pharmacol. 1995 Jul 4;280(2):215-9.
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