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Chemical Structure : NU-6102
Catalog No.: PC-70115Not For Human Use, Lab Use Only.
A potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
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A potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively; exhibits synergistic growth inhibition, and enhanced cytotoxicity in HT29 cells in vitro and HT29 tumour growth inhibition in vivo combined with Pictilisib; induces G2 arrest, inhibition of Rb phosphorylation and cytotoxicity in SKUT-1B cells (LC50=2.6 uM, for a 24h exposure).
| M.Wt | 402.5 | |
| Formula | C18H22N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hardcastle IR, et al. J Med Chem. 2004 Jul 15;47(15):3710-22.
2. Beale G, et al. Br J Cancer. 2016 Sep 6;115(6):682-90.
3. Thomas HD, et al. Eur J Cancer. 2011 Sep;47(13):2052-9.
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