Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NVP-AAC789
Catalog No.: PC-61395Not For Human Use, Lab Use Only.
A potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 20 nM, weakly inhibits VEGFR-1, 3 with IC50 of 180 and 380 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 20 nM, weakly inhibits VEGFR-1, 3 with IC50 of 180 and 380 nM; shows no activity against FGFR-1, FGFR-3, FGFR-4, PDGFR-α, and Tie-2 tyrosine kinases at 10 uM; inhibits VEGF-induced cellular receptor phosphorylation with IC50 of 11.5 nM in cell-based assays, inhibits VEGF-induced HUVE cell proliferation with IC50 of 1.6 nM.
| M.Wt | 405.299 | |
| Formula | C21H17BrN4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Tille JC, et al. J Pharmacol Exp Ther. 2001 Dec;299(3):1073-85.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
