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Chemical Structure : Netazepide
CAS No.: 155488-25-8
Catalog No.: PC-60082Not For Human Use, Lab Use Only.
Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM.
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Netazepide (YF476, Sograzepide) is a potent, selective and orally active gastrin/CCK-2 antagonist with IC50 of 0.1 nM.
Netazepide (YF476, Sograzepide) displays >5,000-fold selectivity over CCK-1 receptors.
Netazepide (YF476, Sograzepide) inhibits pentagastrin-induced gastric acid secretion in anesthetized rats (ED50=87 nM/kg), and shows potential for the treatment of gastroesophageal reflux disease (GERD).
Netazepide (YF476, Sograzepide) also inhibits gastric neuroendocrine enterochromaffin-like (ECL) cell hyperplasia and gastric carcinoid tumor development.
| M.Wt | 498.587 | |
| Formula | C28H30N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-(3-(methylamino)phenyl)urea |
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1. Semple G, et al. J Med Chem. 1997 Jan 31;40(3):331-41.
2. Takinami Y, et al. Aliment Pharmacol Ther. 1997 Feb;11(1):113-20.
3. Takemoto Y, et al. Arzneimittelforschung. 1998 Apr;48(4):403-7.
4. Kidd M, et al. Regul Pept. 2010 Jun 8;162(1-3):52-60.
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