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Chemical Structure : Nx-1607
Catalog No.: PC-21554Not For Human Use, Lab Use Only.
Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.
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Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.
Nx-1607 binds to the TKBD-LHR unit of Cbl-b, locking the protein in an inactive conformation.
Nx-1607 inhibits the interaction between the N-terminal E3 ligase fragment (TKBD-LHR-RING) of Cbl-b and UbcH5B-Ub (E2-Ub) complex in the presence of the Src kinase substrate.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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