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O-phenanthroline

Chemical Structure : O-phenanthroline

CAS No.: 66-71-7

O-phenanthroline (1,10-phenanthroline;Ortho-phenanthroline;OPA)

Catalog No.: PC-61352Not For Human Use, Lab Use Only.

A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM; shows no activity for other DUBs (USP1/USP2/USP4/USP5/USP7/USP8/USP20/UCH37, IC50>50 uM); blocks cellular proteasome function, induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib, activates caspase cascade and endoplasmic stress response signaling; reduces progression of tumor growth and prolongs survival in mice MM xenograft model.

Physicochemical Properties

M.Wt 180.21
Formula C12H8N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4,5-Diazaphenanthrene

References

1. Song Y, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.172.

2. Verma R, et al. Science. 2002 Oct 18;298(5593):611-5.

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