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Chemical Structure : Oliceridine
CAS No.: 1401028-24-7
Catalog No.: PC-61681Not For Human Use, Lab Use Only.
Oliceridine (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg (4 weeks) | $548 | In stock | |
| 100 mg (4 weeks) | $1180 | In stock | |
| 500 mg (4 weeks) | $2580 | In stock | |
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Oliceridine (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1; displays 178-fold selectivity over KOR and 355-fold selectivity over DOR; elicits robust G protein signaling, with potency and efficacy similar to morphine in cell-based assays; is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine in mice and rats.
Pain
Phase 3 Clinical
| M.Wt | 386.55 | |
| Formula | C22H30N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-N-((3-methoxythiophen-2-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethanamine |
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1. Chen XT, et al. J Med Chem. 2013 Oct 24;56(20):8019-31.
2. DeWire SM, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17.
3. Schneider S, et al. Biochemistry. 2016 Nov 22;55(46):6456-6466.
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